For his role as Sheldon Cooper on The Big Bang Theory, he won two consecutive Emmy Awards for Outstanding Lead Actor in a Comedy Series and has received praise from multiple other awards associations.
He studied theater at the University of Houston and the University of San Diego. He earned one of his first film credits as the character Tim in the 2004 film Garden State.
In 2015, he voiced the character Oh in the animated feature Home.
He began a relationship with art director Todd Spiewak in 2002.