He became known for his roles as super villains and for his voice acting work on Robot Chicken. He also appeared in the series NCIS: Los Angeles, Crossing Jordan and Twin Peaks.
He had his first role in the 1983 film The Man Who Wasn't There, in which he played a waiter.
He played the lead villain in the 1997 film Justice League of America.
He married Lori Weintraub in 2005 and he had two sons named Rafael and Lucas. He was the cousin of George Clooney.
He was a frequent a voice-actor in Seth Green's TV series Robot Chicken.