Famous for her role as Mili on the Brazilian soap opera Chiquititas, Grigio is also notable for her television hosting work on the programs Band Kids and Best of Brazil. She has acted in over 5,000 episodes of television throughout her ongoing career.
She began appearing in advertising campaigns when she was less than a year old.
She won the Best of NaTelinha Year Awards in both 2013 and 2014. She has garnered over 7 million followers on her personal Instagram page.
She grew up in Maua, Sao Paulo, Brazil, as the child of Janaina Grigio and Alexandre Marcelo dos Santos. She began a relationship with singer Johnny Baroli.
She and Luisana Lopilato were both in the cast of Chiquititas.