Most famous for his collaboration with cartoonist Mike Krahulik on the popular Penny Arcade webcomic, Holkins is also known for creating a fan fiction parody website called Epic Legends of the Hierarchs: The Elemenstor Saga.
While beginning his career as a webcomic writer, he also pursued work as a singer and guitarist.
He co-founded a successful children's hospital charity known as Child's Play.
He and his wife Brenna settled in Seattle, Washington, and welcomed a son named Elliot in 2005 and a daughter named Ronia in 2009.
He and Girls with Slingshots creator Danielle Corsetto both became known for their work on successful webcomics.