She became famous from playing Agatha Christie's Miss Marple in the popular TV series Miss Marple.
She made her stage debut in 1927, gaining comedic and bizarre roles.
In the 1940s, she starred in Agatha Christie's play Appointment with Death. After seeing her performance, Christie later wrote her a note saying that she hoped one day Hickson would play Miss Marple.
She married Eric Norman Butler in 1932. The couple had a daughter and son.
She played the character Miss Marple in a TV rendition of the book written by Agatha Christie.