Gained a following by posting covers of pop songs by artists such as Austin Mahone and Justin Bieber to his YouTube channel, oftentimes alongside his older sister Darian. He is known for such original songs as "What If" and "Missing You." In 2018, he was cast to star in Total Eclipse.
He started making videos when he was 8 years old and Darian was 13. He and Darian began by creating videos for original songs titled "Summertime," "Replay," and "Never Give Up."
He has over 4.1 million subscribers to his main YouTube channel as well as over one million subscribers to his vlogging channel, Johnny Orlando Vlogs. He appeared on the cover of the March/April 2018 issue of TigerBeat magazine.