Most famous as a cartoonist for The New Yorker, Booth frequently drew images of modern husbands and their wives, cats, and humorously overweight dogs.
Before serving in the U.S. Marine Corps and working as a cartoonist for a military publication called the Leatherneck magazine, he took art classes at the Chicago Academy of Fine Arts and the Corcoran College of Art and Design.
He was the 2010 recipient of the National Cartoonists Society's Milton Caniff Lifetime Achievement Award.
He grew up on a farm in Fairfax, Missouri, as the child of teachers William and Irma Booth. In the 1950s, he settled in New York City and met his future wife, Dione.
He and Syd Hoff both created cartoons for The New Yorker.