Andrew Jackson's political colleague who succeeded him as a senator from Tennessee, an office he served from 1825 to 1840. He notably led efforts in the Senate to pass the Indian Removal Act of 1830
He founded White's Fort, which eventually became Knoxville, Tennessee.
He was on the commission that bought Florida from Spain.
He married Elizabeth Carrick, the daughter of his teacher and mentor Samuel Carrick in 1798.
After he grew suspicious of Andrew Jackson's growing power, he started supporting his rival Henry Clay.