Perhaps most well known for her role as Tami-Lynn in the Seth MacFarlane features Ted (2012) and Ted 2 (2015), Barth is also notable for her guest spots on Parks and Recreation; Melissa & Joey; CSI; and How I Met Your Mother.
Before beginning her screen acting career, she trained at Philadelphia's Wilma Theatre and attended both La Salle University (where she pursued a communications degree) and West Chester University (where she earned a degree in acting and creative writing).
She spent her youth in Philadelphia, Pennsylvania, and later relocated to Los Angeles, California, where she worked as a server at several restaurants before making her television debut in a 2004 episode of The District. In 2008 she married Brett Dicksa but the couple later divorced.
She and Madison Lintz were cast in leading roles in the 2015 horror movie Tell Me Your Name.