Known by the stage name Jhené, she rose to fame as a singer with the American R&B group B2K and released hit songs such as "The Worst" and "Sail Out." In 2018, she released her first poetry collection titled, 2Fish.
When she was starting her career, she was perceived as Lil' Fizz's cousin, although they were not related.
She sang as a guest vocalist on the Pandemonium! song "Tease."
Her parents are Dr. Karamo Chilombo and Christina Yamamoto. She was married to music producer Oladipo Omishore aka Dot da Genius from 2014 until 2017. She began dating Big Sean in October 2016. She has a daughter named Namiko Love from a previous relationship. Her sister Mila J also became a singer. In June 2022, the couple announced they are expecting their first child together. They welcomed a son in November 2022.