The younger sibling of United States President Dwight D. Eisenhower, he had a high-profile career in higher education, serving as president of Pennsylvania State University, Johns Hopkins University, and Kansas State University.
After earning his bachelor's degree from Kansas State University, he became the United States Department of Agriculture's Director of Information and later held an executive position with the War Relocation Authority.
In 1980, he agreed to be the vice-presidential candidate on the Independent presidential ticket of U.S. Congressman John B. Anderson.
Born into poverty in Abilene, Kansas, he was the second son of Elizabeth and David Eisenhower. With his wife Helen Elsie Eakin, he raised children named Milton Jr. and Ruth.