Her acting debut was a small role in the film Hot Dogs for Gaugin'.
She was nominated for 10 Emmy Awards for her role in Cheers and won four of them.
She married Matilda co-star Danny DeVito in 1982 but they later separated in 2017 after 35 years of marriage. They are parents to daughters Lucy and Grace and a son named Jacob Daniel.
She starred on the American situation comedy television series Cheers with fellow actor George Wendt.