After starring in the 2002 Danish film Klatretosen when she was just thirteen years old, Zangenberg continued her rise to fame by appearing on the popular sketch comedy program Live from Bremen and playing a major role in the 2012 film The Caretaker. In 2014, she began starring as Sophie on a Danish television series titled Heartless.
Early in her career, she acted in a short film titled Piece by piece.
She played the role of Emma in the 2004 film Fakir from Bilbao.
She and her two younger siblings grew up in Vanlose and Frederiksberg, Denmark as the children of IT entrepreneurs.
From 2011 until 2014, she was in a relationship with the Danish soccer player Nicklas Bendtner.