Lead vocalist and bassist of the band Primus who has created many side projects, including Colonel Les Claypool's Fearless Flying Frog Brigade.
He auditioned for Metallica as Cliff Burton's successor but did not make the band. He worked as a carpenter before forming Primus.
He wrote a novel called South of the Pumphouse in 2006. He would also begin a wine-making project in 2007.
He married Cheney Claypool; they have two children named Cage Oliver and Lena Tallulah.
His album Les Claypool and the Holy Mackerel presents: Highball with the Devil features Henry Rollins.