With her women's doubles tennis partner Cara Black, Huber won the 2008 U.S. Open; the 2005 and 2007 Wimbledon events; and the 2007 Australian Open. She also won the 2009 French Open and 2010 U.S. Open mixed doubles events with American tennis player Bob Bryan and competed in the Summer Olympics of 2008 and 2012.
During her teenage years, she trained at Hilton Head, South Carolina's Van Der Meer Tennis Academy.
In late 2007, she earned the tennis doubles title of co-World No. 1 (sharing the honor with Cara Black).
She spent the first fifteen years of her life in Durban, South Africa, and the remainder of her youth in the United States. She eventually settled in Houston, Texas, with her husband Tony Huber.
She and Lindsay Davenport were partners in the doubles event at the 2008 Beijing Olympics.