Became the first Puerto Rican boxer to win world titles in four different weight divisions. He was ranked as the world's third best light middleweight by The Ring magazine in 2017.
He competed in the 2000 Sydney Olympics as an amateur.
He signed a multi-fight deal with Golden Boy Productions in 2017.
He married Melissa Guzman in 2008; they have a daughter named Alondra and a son named Miguel III. His brother Jose Cotto and cousins Abner Cotto and Carlos Cotto also became professional boxers.
He defeated Shane Mosely by unanimous decision in 2007.