IBF and IBO Bantamweight Champion, WBC and The Ring Junior Featherweight Champion, and brother of Juan Manuel Marquez.
His first professional fight was an eighth round knockout loss to Bantamweight champion Victor Rabanales.
He was in a car accident on his way to the airport to receive his Fight of the Year award.
He was married to Adriana Lavat from 2001 to 2007. In 2011, he married Jaydy Michel. His older brother is world Lightweight and Featherweight champion Juan Manuel Marquez.
He and Bobby Chacon both competed in bouts that were named Fight of the Year by Ring Magazine.