Famous for his starring roles in such late 1990s and early 2000s Philippine films as Kahit Demonyo Itutumba Ko, Totoy Golem, and Lorenzo's Time, he is also notable for his role as Buhawi Agda on the ABS-CBN series Basta't Kasama Kita.
His early film credits include roles in Blue Jeans Gang and Bad Boy II.
In the mid-1990s, he was arrested for possession of drugs and firearms.
The son of actress Eva Carino and politician Roy Padilla Sr., he grew up with several siblings, including actors Robin Padilla and BB Gandanghari. He has children named Daniel, RJ, Ralph, Roanna and Carmella.