Lead singer of the English 1980s bands Duran Duran, Tin Tin, Dr. Calculus, and The Lilac Time. In 1993, he released his first solo album.
He attended Birmingham Polytechnic (later known as Birmingham City University), where he met musician John Taylor.
A documentary entitled Memory & Desire: 30 Years in the Wilderness with Stephen Duffy & The Lilac Times was made about him and his band.
He married fellow musician Claire Worrall in 2008.
He helped Robbie Williams produce such Barenaked Ladies songs as "Alcohol."