Best known as the sidekick to Conan O'Brien on Conan's late night talk shows. His film credits include Scary Movie 2, Talladega Nights and Elf. He also provided the voice of Mort in the Madagascar film franchise.
He was named prom king in high school.
He played himself and his fictional twin brothers Donnie, Emmett, Rocky and Chareth in a 2006 episode of the FOX series Arrested Development, entitled "S.O.B.s."
He has children named William and Mercy with Sarah Thyre, whom he married in 2004.