He became known as paleontologist Ross Geller on the sitcom Friends, a role for which he won a Screen Actors Guild Award for Outstanding Performance. In 2016, he portrayed Robert Kardashian on the FX series The People v. O. J. Simpson: American Crime Story.
He began acting at Beverly Hills High School, and after graduating college, he co-founded Lookingglass Theatre Company as an unemployed actor.
He supplied the voice for the Giraffe, Melman, in the Madagascar franchise and won a Satellite Award for his role in the miniseries Band of Brothers as Herbert Sobel in 2001.
On Friends, his character Ross had an on-again, off-again relationship with the character Rachel, played by Jennifer Aniston.