American chemist and one of the founders of the field of host-guest chemistry who won the Nobel Prize in Chemistry in 1987 for his work in the new field. He has also published eight books on organic chemistry.
He had to support his family of five after his father died, and he had worked over a dozen jobs by the time he was eighteen.
Cram's rule, which is named after him, gives a model for predicting the outcome of nucleophilic attack of carbonyl compounds.
His father was a Scottish immigrant and his mother was a German immigrant.
He won the Nobel Prize in Chemistry two years after Jerome Karle did.