Remembered for his guest appearances in such 1950s and '60s television series as Perry Mason,
After graduating from Brown University, he appeared in the 1926 Broadway production of The Scarlet Letter. A decade and a half later, he made his on-screen debut in the 1942 movie Commandos Strike at Dawn.
He gave a critically acclaimed performance as U.S. Secretary of State
His twelve-year marriage to Elizabeth Dana Macready resulted in three children, including a son, Michael, who had a career as a screen actor. George Macready's grandson, John Macready, became an Olympic gymnast.
During the 1940s, Macready and his close friend, the famous Hollywood actor Vincent Price, co-owned a Beverly Hills, California art gallery.