Her famous parents married in Colorado on Christmas Eve of 1990. After her birth in 1992, Isabella relocated from Florida to her adoptive parents' home in Los Angeles, California.
In her early adulthood years, she pursued careers in fashion and hairdressing.
She has half-sisters named Sunday Rose and Faith Margaret through her mother's marriage to Keith Urban. She also has a half-sister named Suri through her father's marriage to Katie Holmes. In 2015 she married Max Parker.
She has a brother named Connor Cruise who was also adopted during her parents' marriage.