Won the Best Actress Academy Award in 1983 for her role in Tootsie and appeared in Prozac Nation. In 2009, she won a Screen Actors Guild Award for her role in Grey Gardens. She has also gained praise for her various roles on the FX series American Horror Story and as Joan Crawford on the FX series Feud: Bette and Joan.
She studied to become a mime while in Paris.
She made her film debut in the movie King Kong.
She married Fancisco Grande in 1970 and they remained married for eleven years. She has two daughters named Hannah and Alexandra and a son named Samuel.
Christina Ricci worked with her in the film Prozac Nation.