Perhaps most well known for his portrayal of Nelson 'Big Head' Bighetti on the television series Silicon Valley. He is also recognized for playing Zack Miller on Glory Daze and Kyle on Maron. In 2018, he'd play Doug Wilson in The Front Runner.
While attending Harvard University, he headed a collegiate drama group called Hasty Pudding Theatricals.
He appeared in a 2012 episode of House of Lies and played Dale in two episodes of The Big Bang Theory.
He was born the son of Jewish parents Daniel Brener and Sharon Blend Brener. He married comedian Meghan Falcone.