Voiced The Brain on the Animaniacs sketch Pinky and The Brain and has also voiced characters in the TV series Futurama, The Simpsons, Wabbit and Hey Arnold as well as in the films Team America: World Police, Zootopia and Frozen.
He started out as a stand-up comedy, but family tragedies forced him out of the business.
In film, he voiced Inspector Gadget in the direct-to-video and television titles, and also voiced the skunk Pepe LePew in Space Jam.
His father, Guy LaMarche, was tragically murdered in 1987. He married Robin Wiseman in 1991.
A popular Orson Welles impersonator, he voiced the great thespian's persona on episodes of Pinky and the Brain as well as on The Critic.