Known for his original song "Parchman Farm." He eventually stopped performing it in the 1980s, deeming it politically incorrect.
His family was living in Tippo, Mississipi, when he was born and encouraged his musical talents. He began playing piano in grammar school and later took up the trumpet in high school.
His songs were covered by Van Morrison on an album titled Tell Me Something: The Songs of Mose Allison from 1996.