Between the early 1990s and 2000s, he served two terms as Prime Minister of Lebanon, resigning from office in each case.
After earning his law degree from Cairo University, he served as Lebanon's Minister of Education.
He was a practitioner of Sunni Islam.
Raised in An Nouri, Lebanon, he was the brother of Lebanese Prime Minister Rashid Karami (assassinated in the late 1980s) and the son of another Prime Minister,
In his second term as Prime Minister, Karami succeeded Rafic Hariri.