An American Gothic horror writer, she is best known for Flowers in the Attic, a novel that focuses on the plight of four children locked in an attic. This novel was the first in the Dollanganger series; Andrews' other works include the Casteel Series and the Cutler books.
She experienced a bad fall in her youth and, as a result, suffered from crippling arthritis for most of her life. She published her first novel, Gods of Green Mountain, in 1972.
Her real name was Cleo Virginia Andrews; she wrote under the pen name of V.C. Andrews.
She grew up in Portsmouth, Virginia with several older brothers.
She and Ann Radcliffe are both considered Gothic writers.