She starred as Donna Jo Tanner in 193 episodes of Full House from 1987 to 1995, a role for which she was nominated for six Young Artist Awards. She signed on to reprise the role in the 2016 Netflix follow-up series Fuller House. She also played Summer Van Horne on the series Make It or Break It from 2009 to 2012.
Following the footsteps of her older brother, Kirk Cameron she began her career by acting in various commercials.
She played Carrie in the 1988 film Punchline and Cassandra in the 2007 film The Wager. She also portrayed Megan White in five episodes of St. Elsewhere.