She earned her on-screen debut in the 2003 film The Bog Creatures. She appeared as Susan Beth.
She gained widespread popularity for her 2008 appearance as Missy Cooper in an episode of The Big Bang Theory.
She married Ross Kohn in October 2015; they had a son named Oscar in February 2017. They had their second child in 2019.
She appeared as the fictional twin sister of Jim Parsons' popular character Sheldon Cooper on The Big Bang Theory.