Best known as the voice of Homer Simpson, he's also voiced many other popular Simpsons characters, including Grampa, Barney Gumble, Krusty the Clown, and Mayor Quimby.
As a college student, he studied art education and hoped to become an art teacher.
In 1995, he performed in a one-man show called Where Did Vincent van Gogh? He was cast as Mr. Kenny in the 2015 blockbuster Fantastic Four.
He married Deb Lacusta in 1987.
He and Hank Azaria both voice an array of characters on The Simpsons.