She began acting onstage at the Neighborhood Playhouse in NYC.
She became an opponent of plastic surgery and a blogger for the Huffington Post. She won a Golden Globe in 2004 for her role in Something's Gotta Give.
She adopted her daughter, Dexter, in 1996, and her son, Duke, in 2001.
She gained a reputation for her role as a comic actress after starring with Woody Allen in Love and Death and Annie Hall.