She co-starred with Paul Reiser in the sitcom Mad About You and appeared in the successful films As Good As it Gets and The Sessions. She also appeared in Cast Away and Pay It Forward.
She went to several plays each week as a child and later practiced ballet and attended UCLA.
She appeared in an episode of The Simpsons as Moe's girlfriend at a time when she was dating Hank Azaria, who provides the voice of Moe.
She began dating Matthew Carnahan in 2001. She and Matthew have a daughter named Makena. She was previously married to Hank Azaria.
She co-starred with Mel Gibson in the 2000 romantic comedy film What Women Want.