Notable for her LGBT rights activism, Jennings was born male but embraced her female transgender identity at a young age. The subject of a YouTube video series titled I am Jazz, she also began starring in a TLC docu-series under the same name in July of 2015.
When she was just four years old, she received a gender identity disorder diagnosis. Two years later, she began appearing on live television with her parents to discuss her childhood as a transgender person.
Time magazine included her on its 2014 list of "25 Most Influential Teens." She was accepted to Harvard University as an undergraduate in 2019.
She appeared with transgender man and fellow LGBT activist Chaz Bono on an episode of The Rosie Show.