Best known for his role as a werewolf in HBO's True Blood, he's had recurring television roles on ER, One Tree Hill, and How I Met Your Mother.
He made his official acting debut in the 2002 film version of Spider-Man, a role he auditioned for only a short time after moving out to Los Angeles.
He was a roadie for the band Goldfinger and became good friends with lead singer, John Feldmann.
He dated actress Demi Moore in 2012, and in November 2015, he married Modern Family star Sofia Vergara.
He reunited with former Carnegie Mellon University classmate Matthew Bomer onscreen in an episode of his show White Collar and in the 2012 film Magic Mike.