She studied pre-dentistry in Colombia for three years before pursuing a career in modeling.
She has been nominated for a Golden Globe Award, a Screen Actors Guild Award, and multiple Emmy Awards for her comedic acting on the hit show Modern Family. In 2020, she became a judge on America's Got Talent.
She has a sister named Sandra. Her older brother, Rafael, was murdered in Bogota in 1998. She married Joe Gonzalez in 1991, and the couple had a son named Manolo before divorcing in 1993. She was engaged to Nick Loeb until the couple separated in May 2014. She then married actor Joe Manganiello in November 2015. They announced their separation in July 2023.