She began acting at the age of 11 in La MaMa Theatre Company in New York City. Her first film role was in I Love You, I Love You Not in 1996.
She earned a both a Golden Globe and a Primetime Emmy Award for her recurring role in the Showtime series Dexter.
She began dating actor David Harbour in 2011, but they later broke up. In 2015, she became engaged to Preston J. Cook; they eventually tied the knot in September 2017. In October 2017, they had a son named Strummer.