Most famous for her role as Danielle Chase on the 1990s teen series My So-Called Life, Wilhoit is also notable for her voice acting work on the animated series Family Guy.
Early in her childhood acting career, she played a small role in the 1991 film Hook.
When not on set, she pursued interests in horseback riding and snowboarding.
A native of Los Angeles, California, she attended Granada Hills High School. Her cousins Dylan and Blake Tuomy-Wilhoit both appeared on the popular TV series Full House.
She appeared with Cameron Douglas in the 2005 comedy movie National Lampoon's Adam & Eve.