A Canadian comedian and writer, he is best known for co-creating and starring in the Comedy Central series Nathan for You and for writing comedy sketches on TV shows such as Canadian Idol and Important Things with Demetri Martin. In 2006, he was given the Tim Sims award for Outstanding Canadian Comedy Newcomer. In 2022, he released the first season of his popular HBO show The Rehearsal.
He studied business at the University of Victoria and graduated with a bachelor of commerce in 2005.
He was a member of Point Grey Secondary School's improv comedy group, which also featured Seth Rogen. He had a small role in the comedy film The Disaster Artist in 2017.
He was born in Vancouver, British Columbia. His parents were both social workers. He divorced from his first wife in 2015.