IBO, NABO, IBU, and EBA Light Middleweight champion, winner of the reality series The Contender.
He fought his first fight at age 9 and won the bronze medal at the 2000 Eastern Olympic Trials.
He wears the Italian flag on his boxing trunks to show pride in his Italian heritage.
His father is world kickboxing champion Peter Manfredo Sr.
He lost to Florida's Jeff Lacy via unanimous decision on December 8, 2007.