Former WBA and WBC Welterweight Champion as well as WBC Light Middleweight Champion, known for his slow and deliberate style.
His first professional fight was a knockout win against Adolfo Salazar on December 16, 2000.
He was featured on the December 2003 cover of The Ring magazine with a headline that read "The craziest man in the sport: Mayorga lights up boxing."
He married Shelsia Hislop in 2003.
His final fight was a loss to Puerto Rico's Miguel Cotto on March 12, 2011.