Most famous for her work on the Australian Broadcasting Corporation programs The Investigators and The 7.30 Report, Henderson is also known for hosting Holiday and Australia's Most Wanted.
After graduating from The Geelong College, she began her career in broadcast journalism by working as a reporter for Melbourne's Channel 7; Brisbane's Channel 9; and Melbourne's Channel 10.
A politician as well as a television personality, she represented the Liberal Party in the 2009 and 2012 Australian federal elections, winning the latter race for a Corangamite constituency seat in the Australian Parliament.
Her mother, Ann Henderson, also had a prominent political career in Australia. Sarah Henderson's marriage to fellow Liberal Party politician Simon Ramsay resulted in one child.
She and Jennifer Byrne are both notable Australian broadcast journalists.