Guitarist for the jam rock band Phish who wrote alone or co-wrote more than one hundred and fifty of their songs. He has his own band named the Trey Anastasio Band, as well as a solo career.
He met future bandmate Steve Pollak in grade school.
He co-wrote the music for the Broadway musical Hands on a Hardbody, being nominated for a Tony Award for his score contributions.
His mother, Dina, was the editor of Sesame Street Magazine. He and Susan Eliza Statesir, his wife, have two daughters named Elizabeth and Isabella.
In addition to writing music for Phish, he has also worked with the composer Philip Glass.