Starred as Cindy Campbell in the Scary Movie film franchise. She also played Zoey in The Dictator and co-produced and starred in the 2008 film The House Bunny. She played the lead character Christy on the CBS series Mom.
She appeared in a frozen-yogurt commercial while in high school.
She played Erica in the last season of the TV series Friends. She began hosting the podcast Anna Faris is Unqualified.
She was married to Ben Indra from 2004 to 2007, and then was married to Chris Pratt from 2009 until 2017. She and Pratt have a son named Jack together. In October 2017, she began dating cinematographer Michael Barrett; she confirmed their engagement in 2020. In July 2021, she revealed that they had eloped.