He gained fame with Gnarls Barkley, whose hit song "Crazy" was voted the best song of the 2000s by Rolling Stone Magazine. His song "Forget You" rose to #2 on the U.S. Billboards in 2010 and he is also known for being a judge on the NBC talent show The Voice.
He co-founded Goodie Mob with Big Gipp, Khujo, and T-Mo, and collaborated with OutKast on their 1994 album Southernplayalisticadillacmuzik.
He lost his father when he was two. His mother, a volunteer firefighter, became paralyzed after surviving an auto collision when he was 16 and died when he was 18. He had a child named Kingston with Christina Johnson, whom he divorced in 2005.
He served as one of the judges for the TV show The Voice with Adam Levine.