Breaking through as an actor after booking the role of Philip Stacy in both The Amazing Spider-Man and The Amazing Spider-Man 2, he would later land the supporting role of Wes in the 2015 film Pass the Light.
He kicked off his professional acting career by booking an uncredited role in Shake It Up! in 2010 and later appearing in a couple episodes of Days of Our Lives.
In 2015, he booked guest-starring roles on ABC's The Goldbergs and MTV's Awkward.
He is the younger brother of actor Jack DePew.
He plays the on-screen sister of Emma Stone's Gwen Stacy in the Amazing Spider-Man series.