Plays Stella on HBO's Bored to Death and created the viral video series Marcell the Shell With Shoes On. She also stars in the 2014 film Obvious Child and plays Mona-Lisa on NBC's Parks and Recreation. In 2016, she voiced Bellwether in the film Zootopia.
She studied literature at Columbia University, where she also co-founded the improv group Fruit Paunch.
She was married to filmmaker Dean Fleischer-Camp from 2012 until 2016. She dated actor Chris Evans from 2016 to 2018. In 2019, she got engaged to Ben Shattuck. In early February 2021, Slate gave birth to a baby girl named Ida.