Starring as Tree Gelbman in the 2017 slasher film Happy Death Day, Rothe was featured in the Academy Award-winning musical La La Land the year prior. On TV, she was a series regular in the MTV show Mary + Jane. She was cast as Julie Richman in 2018's remake of Valley Girl and as Tree in Happy Death Day 2U.
She graduated from Cheery Creek High School.
In 2010, she appeared on America's Most Wanted: America Fights Back. The next year, she booked guest-starring roles in The Onion News Network and ABC's Happy Endings.
She was born Jessica Rothenberg to parents Susan and Steve Rothenberg.
She worked with Logan Paul on Valley Girl.